Publications
50. Divergent roles for antigenic drive in the aetiology of primary versus dasatinib-associated CD8+ TCR-Vβ+ expansions.
Lissina, A., J. E. McLaren, M. Ilander, E. I. Andersson, C. S. Lewis, M. Clement, A. Herman, K. Ladell, S. Llewellyn-Lacey, K. L. Miners, E. Gostick, J. J. Melenhorst, A. J. Barrett, D. A. Price, S. Mustjoki & L. Wooldridge. 2018. Divergent roles for antigenic drive in the aetiology of primary versus dasatinib-associated CD8+ TCR-Vβ+ expansions. Sci Rep. Feb 7;8(1):2534. To read the publication, please click the PubMed link button below:...Read More49. CD8+ T-cell specificity is compromised at a defined MHCI/CD8 affinity threshold.
Dockree, T., C. J. Holland, M. Clement, K. Ladell, J. E. McLaren, H. A. van den Berg, E. Gostick, L. M. K, S. Llewellyn-Lacey, J. S. Bridgeman, S. Man, M. Bailey, S. R. Burrows, D. A. Price, and L. Wooldridge. 2017. CD8+ T-cell specificity is compromised at a defined MHCI/CD8 affinity threshold. Immunol Cell Biol 95:68-76. To read the publication, please click the PubMed link button below:...Read More48. Structural mechanism underpinning cross-reactivity of a CD8+ T-cell clone that recognises a peptide derived from human telomerase reverse transcriptase.
Cole, D. K., H. A. van den Berg, A. Lloyd, M. D. Crowther, K. Beck, J. Ekeruche-Makinde, J. J. Miles, A. M. Bulek, G. Dolton, A. J. Schauenburg, A. Wall, A. Fuller, M. Clement, B. Laugel, P. J. Rizkallah, L. Wooldridge*, and A. K. Sewell*. 2017. Structural mechanism underpinning cross-reactivity of a CD8+ T-cell clone that recognises a peptide derived from human telomerase reverse transcriptase. J Biol Chem 292:802-813. (*authors contributed equally). To read the publication, please click the PubMed link button below:...Read More47. Targeted suppression of autoreactive CD8+ T-cell activation using blocking anti-CD8 antibodies.
Clement, M., J. A. Pearson, S. Gras, H. A. van den Berg, A. Lissina, S. Llewellyn-Lacey, M. D. Willis, T. Dockree, J. E. McLaren, J. Ekeruche-Makinde, E. Gostick, N. P. Robertson, J. Rossjohn, S. R. Burrows, D. A. Price, F. S. Wong, M. Peakman, A. Skowera, and L. Wooldridge. 2016. Targeted suppression of autoreactive CD8+ T-cell activation using blocking anti-CD8 antibodies. Sci Rep Oct 17;6:35332. To read the publication, please click the PubMed link button below:...Read More46. Identification of human viral protein-derived ligands recognized by individual major histocompatibility complex class I (MHCI)-restricted T-cell receptors.
Szomolay, B., J. Liu, P. E. Brown, J. J. Miles, M. Clement, S. Llewellyn-Lacey, G. Dolton, J. Ekeruche-Makinde, A. Lissina, A. J. Schauenburg, A. K. Sewell, S. R. Burrows, M. Roederer, D. A. Price, L. Wooldridge*, and H. A. van den Berg*. 2016. Identification of human viral protein-derived ligands recognized by individual major histocompatibility complex class I (MHCI)-restricted T-cell receptors. Immunol Cell Biol. Jul;94(6):573-82 (*authors contributed equally). To read the publication, please click the PubMed link button below:...Read More45. Lack of Heterologous Cross-reactivity toward HLA-A*02:01 Restricted Viral Epitopes Is Underpinned by Distinct alphabeta T Cell Receptor Signatures.
Grant, E. J., T. M. Josephs, S. A. Valkenburg, L. Wooldridge, M. Hellard, J. Rossjohn, M. Bharadwaj, K. Kedzierska, and S. Gras. 2016. Lack of Heterologous Cross-reactivity toward HLA-A*02:01 Restricted Viral Epitopes Is Underpinned by Distinct alphabeta T Cell Receptor Signatures. J Biol Chem 291:24335-24351. To read the publication, please click the PubMed link button below:...Read More44. Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity.
Cole, D. K., A. M. Bulek, G. Dolton, A. J. Schauenberg, B. Szomolay, W. Rittase, A. Trimby, P. Jothikumar, A. Fuller, A. Skowera, J. Rossjohn, C. Zhu, J. J. Miles, M. Peakman, L. Wooldridge, P. J. Rizkallah, and A. K. Sewell. 2016. Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity. J Clin Invest 126:2191-2204. To read the publication, please click the PubMed link button below:...Read More43. Clinical research: developing an appropriate career structure.
Mellanby, R. J., J. Price, L. Wooldridge, N. N. Jonsson, P. D. Clegg, R. D. Emes, G. Engalnd, S. A. Corr, R. J. Piercy, G. Mulcahy, J. L. Wood, B. R. Walker, and D. J. Argyle. 2015. Clinical research: developing an appropriate career structure. Vet Rec. Nov 28 177: 544-7. To read the publication, please click the PubMed link button below:...Read More42. Naive CD8 T-cell precursors display structured TCR repertoires and composite antigen-driven selection dynamics.
Neller, M. A., K. Ladell, J. E. McLaren, K. K. Matthews, E. Gostick, J. M. Pentier, G. Dolton, A. J. Schauenburg, D. Koning, A. I. Fontaine Costa, T. S. Watkins, V. Venturi, C. Smith, R. Khanna, K. Miners, M. Clement, L. Wooldridge, D. K. Cole, D. van Baarle, A. K. Sewell, S. R. Burrows, D. A. Price, and J. J. Miles. 2015. Naive CD8 T-cell precursors display structured TCR repertoires and composite antigen-driven selection dynamics. Immunol Cell Biol. Mar 24 [epub ahead of print]. To read the publication, please click the PubMed link button below:...Read More41. Epitope specificity delimits the functional capabilities of vaccine-induced CD8 T cell populations.
Hill, B. J., P. A. Darrah, Z. Ende, D. R. Ambrozak, K. M. Quinn, S. Darko, E. Gostick, L. Wooldridge, H. A. van den Berg, V. Venturi, M. Larsen, M. P. Davenport, R. A. Seder, D. A. Price, and D. C. Douek. 2014. Epitope specificity delimits the functional capabilities of vaccine-induced CD8 T cell populations. J Immunol 193:5626-5636. To read the publication, please click the PubMed link button below:...Read More40. Co-Receptor CD8-Mediated Modulation of T-Cell Receptor Functional Sensitivity and Epitope Recognition Degeneracy.
Szomolay, B., T. Williams, L. Wooldridge, and H. A. van den Berg. 2014. Co-Receptor CD8-Mediated Modulation of T-Cell Receptor Functional Sensitivity and Epitope Recognition Degeneracy. Front Immunol 4:329. To read the publication, please click the PubMed link button below:...Read More39. Cellular-level versus receptor-level response threshold hierarchies in T-cell activation.
van den Berg, H. A., K. Ladell, K. Miners, B. Laugel, S. Llewellyn-Lacey, M. Clement, D. K. Cole, E. Gostick, L. Wooldridge, A. K. Sewell, J. S. Bridgeman, and D. A. Price. 2013. Cellular-level versus receptor-level response threshold hierarchies in T-cell activation. Front Immunol 4:250. To read the publication, please click the PubMed link button below:...Read More38. Individual MHCI-restricted T-cell receptors are characterized by a unique peptide recognition signature.
Wooldridge, L. 2013. Individual MHCI-restricted T-cell receptors are characterized by a unique peptide recognition signature. Frontiers in Immunology 4:199. To read the publication, please click the PubMed link button below:...Read More37. Peptide length determines the outcome of T cell receptor/peptide-MHCI engagement.
Ekeruche, J., J. J. Miles, H. A. van den Berg, A. Skowera, D. Cole, A. J. Schauenburg, M. Ping Tan, J. M. Pentier, S. Llewellyn-Lacey, K. M. Miles, A. M. bulek, M. Clement, T. Williams, A. Trimby, M. Bailey, P. Rizkallah, J. Rossjohn, M. Peakman, D. A. Price, S. R. Burrows, A. K. Sewell, and L. Wooldridge. 2013. Peptide length determines the outcome of T cell receptor/peptide-MHCI engagement. Blood 121:1112-23. To read the publication, please click the PubMed link button below:...Read More36. The Nucleocapsid Protein of Rift Valley Fever Virus is a Potent Human CD8+ T Cell Antigen and Elicits Memory Responses.
Weidong X., D. M. Watts, M. C. Costanzo, L. A. Venegas, F. Jiao, X. Tang, A. Sette2, J. Sidney, A. K. Sewell, L. Wooldridge, S. Makino, J. C. Morrill, C. J. Peters, and J. Kan-Mitchell. 2013. The Nucleocapsid Protein of Rift Valley Fever Virus is a Potent Human CD8+ T Cell Antigen and Elicits Memory Responses. Plos One 8:e59210. To read the publication, please click the PubMed link button below:...Read More35. T-cell receptor-optimized peptide skewing of the T-cell repertoire can enhance antigen targeting
Ekeruche-Makinde J, Clement M, Cole DK, Edwards ES, Ladell K, Miles JJ, Matthews KK, Fuller A, Lloyd KA, Madura F, Dolton GM, Pentier J, Lissina A, Gostick E, Baxter TK, Baker BM, Rizkallah PJ, Price DA, Wooldridge L, Sewell AK. 2012. T-cell receptor-optimized peptide skewing of the T-cell repertoire can enhance antigen targeting. J Biol Chem. 287:37269-81. To read the publication, please click the PubMed link button below:...Read More34. Human beta-Cell Killing by Autoreactive Preproinsulin-Specific CD8 T Cells Is Predominantly Granule-Mediated With the Potency Dependent Upon T-Cell Receptor Avidity
Knight, R. R., D. Kronenberg, M. Zhao, G. C. Huang, M. Eichmann, A. Bulek, L. Wooldridge, D. K. Cole, A. K. Sewell, M. Peakman, and A. Skowera. 2013. Human beta-Cell Killing by Autoreactive Preproinsulin-Specific CD8 T Cells Is Predominantly Granule-Mediated With the Potency Dependent Upon T-Cell Receptor Avidity. Diabetes 62: 205-13. To read the publication, please click the PubMed link button below:...Read More33. The molecular determinants of CD8 co-receptor function
Cole DK, Laugel B, Clement M, Price DA, Wooldridge L, Sewell AK. 2012. The molecular determinants of CD8 co-receptor function. J Leuk Biol 137:139-48. To read the publication, please click the PubMed link button below:...Read More32. A single autoimmune T cell receptor recognizes more than a million different peptides
Wooldridge, L., J. Ekeruche-Makinde, H. A. van den Berg, A. Skowera, J. J. Miles, M. P. Tan, G. Dolton, M. Clement, S. Llewellyn-Lacey, D. A. Price, M. Peakman, and A. K. Sewell. 2012. A single autoimmune T cell receptor recognizes more than a million different peptides. J Biol Chem 287:1168-1177. IF: 5.328. **The first time that CD8+ T-cell crossreactivity has been quantified. To read the publication, please click the PubMed link button below:...Read More31. Structural basis for the killing of human beta cells by CD8(+) T cells in type 1 diabetes
Bulek, A. M., D. K. Cole, A. Skowera, G. Dolton, S. Gras, F. Madura, A. Fuller, J. J. Miles, E. Gostick, D. A. Price, J. W. Drijfhout, R. R. Knight, G. C. Huang, N. Lissin, P. E. Molloy, L. Wooldridge, B. K. Jakobsen, J. Rossjohn, M. Peakman, P. J. Rizkallah, and A. K. Sewell. 2012. Structural basis for the killing of human beta cells by CD8(+) T cells in type 1 diabetes. Nat Immunol 13:283-289. IF: 26 **First autoreactive human TCR/pMHCI structure. To read the publication, please click the PubMed link button below:...Read More30. The multiple roles of the CD8 coreceptor in T cell biology: oppurtunities for the selective modulation of self-reactive cytotoxic T cells
Laugel, B., D.K. Cole, M. Clement, L. Wooldridge, D.A. Price, and A. Sewell, K. 2011. The multiple roles of the CD8 coreceptor in T cell biology: oppurtunities for the selective modulation of self-reactive cytotoxic T cells. J Leukoc Biol 90: 1089-1099. IF: 4.4. To read the publication, please click the PubMed link button below:...Read More29. Escape from highly effective public CD8+ T-cell clonotypes by HIV
Iglesias, M.C., J.R. Almeida, S. Fastenackels, D.J. van Bockel, M. Hashimoto, V. Venturi, E. Gostick, A. Urrutia, L. Wooldridge, M. Clement, S. Gras, P.G. Wilmann, B. Autran, A. Moris, J. Rossjohn, M.P. Davenport, M. Takiguchi, C. Brander, D.C. Douek, A.D. Kelleher, D.A. Price, and V. Appay. 2011. Escape from highly effective public CD8+ T-cell clonotypes by HIV. Blood 118:2138-2149. IF: 10.558. To read the publication, please click the PubMed link button below:...Read More28. Anti-CD8 antibodies can trigger CD8 T cell effector function in the absence of TCR engagement and improve peptide-MHCI tetramer staining
Clement, M., K. Ladell, J. Ekeruche-Makinde, J.J. Miles, E.S. Edwards, G. Dolton, T. Williams, A.J. Schauenburg, D.K. Cole, S.N. Lauder, A.M. Gallimore, A.J. Godkin, S.R. Burrows, D.A. Price, A.K. Sewell, and L. Wooldridge. 2011. Anti-CD8 antibodies can trigger CD8 T cell effector function in the absence of TCR engagement and improve peptide-MHCI tetramer staining. J Immunol 187:654-663. IF: 5.745. **Highlights the highly variable cell surface effects observed with anti-CD8 antibodies and how correct interpretation is critical when using these reagents. This paper will have an impact on the way that T cell activation assays are performed. Faculty1000 has placed this Continue Reading...Read More27. Use of PKI in cell staining/detection
Sewell, A. K. and L. Wooldridge. 2010. Use of PKI in cell staining/detection. International Patent PCT/GB2009/002251 March 25. **Patent obtained for the invention of a new technology that enhances the detection of low avidity T cells using pMHC tetramers, now licensed to Immudex. To read the publication, please click the PubMed link button below:...Read More26. Genetic and structural basis for selection of a ubiquitous T cell receptor deployed in Epstein-Barr virus infection
Miles, J.J., A.M. Bulek, D.K. Cole, E. Gostick, A.J. Schauenburg, G. Dolton, V. Venturi, M.P. Davenport, M.P. Tan, S.R. Burrows, L. Wooldridge, D.A. Price, P.J. Rizkallah, and A.K. Sewell. 2010. Genetic and structural basis for selection of a ubiquitous T cell receptor deployed in Epstein-Barr virus infection. PLoS Pathog 6:e1001198. IF: 9.079. To read the publication, please click the PubMed link button below:...Read More25. CD8 controls T cell cross-reactivity
Wooldridge, L., B. Laugel, J. Ekeruche, M. Clement, H.A. van den Berg, D.A. Price, and A.K. Sewell. 2010. CD8 controls T cell cross-reactivity. J Immunol 185:4625-4632. IF: 5.745. **The first description of an important controlling mechanism for T cell crossreactivity. To read the publication, please click the PubMed link button below:...Read More24. Modification of MHC anchor residues generates heteroclitic peptides that alter TCR binding and T cell recognition
Cole, D.K., E.S. Edwards, K.K. Wynn, M. Clement, J.J. Miles, K. Ladell, J. Ekeruche, E. Gostick, K.J. Adams, A. Skowera, M. Peakman, L. Wooldridge, D.A. Price, and A.K. Sewell. 2010. Modification of MHC anchor residues generates heteroclitic peptides that alter TCR binding and T cell recognition. J Immunol 185:2600-2610. IF: 5.745. To read the publication, please click the PubMed link button below:...Read More23. Ca2+ release from the endoplasmic reticulum of NY-ESO-1-specific T cells is modulated by the affinity of TCR and by the use of the CD8 coreceptor
Chen, J. L., A. J. Morgan, G. Stewart-Jones, D. Shepherd, G. Bossi, L. Wooldridge, S. L. Hutchinson, A. K. Sewell, G. M. Griffiths, P. A. van der Merwe, E. Y. Jones, A. Galione, and V. Cerundolo. 2010. Ca2+ release from the endoplasmic reticulum of NY-ESO-1-specific T cells is modulated by the affinity of TCR and by the use of the CD8 coreceptor. J Immunol 184:1829-1839. IF: 5.745. To read the publication, please click the PubMed link button below:...Read More22. MHC class I molecules with Superenhanced CD8 binding properties bypass the requirement for cognate TCR recognition and nonspecifically activate CTLs
Wooldridge, L., M. Clement, A. Lissina, E. S. Edwards, K. Ladell, J. Ekeruche, R. E. Hewitt, B. Laugel, E. Gostick, D. K. Cole, R. Debets, C. Berrevoets, J. J. Miles, S. R. Burrows, D. A. Price, and A. K. Sewell. 2010. MHC class I molecules with Superenhanced CD8 binding properties bypass the requirement for cognate TCR recognition and nonspecifically activate CTLs. J Immunol 184:3357-3366. IF: 5.745. **First paper to establish the biological significance of the low solution binding affinity of the pMHCI/CD8 interaction. To read the publication, please click the PubMed link button below:...Read More21. Protein kinase inhibitors substantially improve the physical detection of T-cells with peptide-MHC tetramers
Lissina, A., K. Ladell, A. Skowera, M. Clement, E. Edwards, R. Seggewiss, H. A. van den Berg, E. Gostick, K. Gallagher, E. Jones, J. J. Melenhorst, A. J. Godkin, M. Peakman, D. A. Price, A. K. Sewell and L. Wooldridge. 2009. Protein kinase inhibitors substantially improve the physical detection of T-cells with peptide-MHC tetramers. J Immunol Methods 340:11-24. IF: 2.340. **Important advance in improving tetramer technology, protected by Patent PCT/GB2009/002251 (See Pub#6). To read the publication, please click the PubMed link button below:...Read More20. Tricks with tetramers: how to get the most from multimeric peptide-MHC
Wooldridge, L., A. Lissina, D. K. Cole, H. A. van den Berg, D. A. Price, and A. K. Sewell. 2009. Tricks with tetramers: how to get the most from multimeric peptide-MHC. Immunology 126:147-164. IF: 3.302. **One of the most highly cited articles published by Immunology in 2010. Cited 20 times so far. Describes the advances to pMHCI tetramer technology that we have achieved. To read the publication, please click the PubMed link button below:...Read More19. Identifying heteroclitic peptides that mimic the major CTL target on preproinsulin in Type I diabetes
Skowera, A., J. J. Miles, L. Wooldridge, D. K. Cole, A. Zaremba, R. J. Ellis, A. K. Sewell, and M. Peakman. 2009. Identifying heteroclitic peptides that mimic the major CTL target on preproinsulin in Type I diabetes. Clinical Immunology 131:S88-S88. IF: 3.932. To read the publication, please click the PubMed link button below:...Read More18. ELISPOT and functional T cell analyses using HLA mono-specific target cells
Horlock, C., B. Stott, J. Dyson, G. Ogg, T. McPherson, L. Jones, A. K. Sewell, L. Wooldridge, D. K. Cole, J. Stebbing, and P. Savage. 2009. ELISPOT and functional T cell analyses using HLA mono-specific target cells. J Immunol Methods 350:150-160. IF: 5.745. To read the publication, please click the PubMed link button below:...Read More17. Profound inhibition of antigen-specific T-cell effector functions by dasatinib
Weichsel, R., C. Dix, L. Wooldridge, M. Clement A. Fenton-May, A. K. Sewell, J. Zezula, E. Greiner, E. Gostick, D. A. Price, H. Einsele, and R. Seggewiss. 2008. Profound inhibition of antigen-specific T-cell effector functions by dasatinib. Clinical Cancer Res 14:2484-2491. IF: 7.338. **Important description of the in vitro effects of dasatinib on T cell function. I performed in vitro experiments on T cell clones to demonstrate this effect and elucidate the mechanism. I also co-wrote the manuscript. Cited 25 times. To read the publication, please click the PubMed link button below:...Read More16. Techniques to improve the direct ex vivo detection of low frequency antigen-specific CD8+ T cells with peptide-major histocompatibility complex class I tetramers
Chattopadhyay, P. K., J. J. Melenhorst, K. Ladell, E. Gostick, P. Scheinberg, A. J. Barrett, L. Wooldridge, M. Roederer, A. K. Sewell, and D. A. Price. 2008. Techniques to improve the direct ex vivo detection of low frequency antigen-specific CD8+ T cells with peptide-major histocompatibility complex class I tetramers. Cytometry A 73:1001-1009. IF: 3.749. To read the publication, please click the PubMed link button below:...Read More15. Detection of low avidity CD8(+) T cell populations with coreceptor-enhanced peptide-major histocompatibility complex class I tetramers
Melenhorst, J. J., P. Scheinberg, P. K. Chattopadhyay, A. Lissina, E. Gostick, D. K. Cole, L. Wooldridge, H. A. van den Berg, E. Bornstein, N. F. Hensel, D. C. Douek, M. Roederer, A. K. Sewell, A. J. Barrett, and D. A. Price. 2008. Detection of low avidity CD8(+) T cell populations with coreceptor-enhanced peptide-major histocompatibility complex class I tetramers. J Immunol Methods 338:31-39. IF: 5.745. To read the publication, please click the PubMed link button below:...Read More14. Enhanced immunogenicity of CTL antigens through mutation of the CD8 binding MHC class I invariant region
Wooldridge, L., A. Lissina, J. Vernazza, E. Gostick, B. Laugel, S. L. Hutchinson, F. Mirza, P. R. Dunbar, J. M. Boulter, M. Glick, V. Cerundolo, H. A. van den Berg, D. A. Price, and A. K. Sewell. 2007. Enhanced immunogenicity of CTL antigens through mutation of the CD8 binding MHC class I invariant region. Eur J Immunol 37:1323-1333. IF: 4.942. **A paper which examined the biological effects of enhancing the strength of the pMHCI/CD8 interaction. This had never been achieved before and provides a novel way in which to enhance pMHCI specific immunity. Cited 20 times. To read the publication, Continue Reading...Read More13. Coreceptor CD8-driven modulation of T cell antigen receptor specificity
van den Berg, H. A., L. Wooldridge, B. Laugel, and A. K. Sewell. 2007. Coreceptor CD8-driven modulation of T cell antigen receptor specificity. J Theor Biol 249:395-408. IF: 2.371. To read the publication, please click the PubMed link button below:...Read More12. Different T cell receptor affinity thresholds and CD8 coreceptor dependence govern cytotoxic T lymphocyte activation and tetramer binding properties
Laugel, B., H. A. van den Berg, E. Gostick, D. K. Cole, L. Wooldridge, J. Boulter, A. Milicic, D. A. Price, and A. K. Sewell. 2007. Different T cell receptor affinity thresholds and CD8 coreceptor dependence govern cytotoxic T lymphocyte activation and tetramer binding properties. J Biol Chem 282:23799-23810. IF: 5.328. To read the publication, please click the PubMed link button below:...Read More11. Functional and biophysical characterization of an HLA-A*6801-restricted HIV-specific T cell receptor
Gostick, E., D. K. Cole, S. L. Hutchinson, L. Wooldridge, S. Tafuro, B. Laugel, A. Lissina, A. Oxenius, J. M. Boulter, D. A. Price, and A. K. Sewell. 2007. Functional and biophysical characterization of an HLA-A*6801-restricted HIV-specific T cell receptor. Eur J Immunol 37:479-486. IF: 4.942. To read the publication, please click the PubMed link button below:...Read More10. Anti-coreceptor antibodies profoundly affect staining with peptide-MHC class I and class II tetramers
Wooldridge, L., T. J. Scriba, A. Milicic, B. Laugel, E. Gostick, D. A. Price, R. E. Phillips, and A. K. Sewell. 2006. Anti-coreceptor antibodies profoundly affect staining with peptide-MHC class I and class II tetramers. Eur J Immunol 36:1847-1855. IF: 4.942. To read the publication, please click the PubMed link button below:...Read More9. Avidity for antigen shapes clonal dominance in CD8+ T cell populations specific for persistent DNA viruses
Price, D. A., Brenchley, J. M., Ruff, L. E., Betts, M. R., Hill, B. J., Roederer, M., Koup, R. A., Migueles, S. A., Gostick, E., Wooldridge, L., Sewell, A. K., Connors, M. and Douek, D.C. 2005. Avidity for antigen shapes clonal dominance in CD8+ T cell populations specific for persistent DNA viruses. J Exp Med 202:1349-1361. IF: 14.5. **Cited 113 times. I provided reagents and expertise for this study which elucidates the factors that govern clonal selection during viral infection. To read the publication, please click the PubMed link button below:...Read More8. Interaction between the CD8 coreceptor and MHC class I stabilizes TCR-antigen complexes at the cell surface
Wooldridge, L., van den Berg, H., Glick, M., Gostick, E., Laugel, B., Hutchinson, S. L., Milicic, A., Brenchley, J. M., Douek, D. C., Price, D. A., and Sewell, A. K. 2005. Interaction between the CD8 coreceptor and MHC class I stabilizes TCR-antigen complexes at the cell surface. J Biol Chem 280:27491-27501. IF: 5.328. **First paper to demonstrate that the TCR/pMHCI interaction can be stabilized by the CD8 coreceptor. Cited 50 times. To read the publication, please click the PubMed link button below:...Read More7. Structural and kinetic basis for heightened immunogenicity of T-cell vaccines
Chen, J. L., Stewart-Jones, G., Bossi, G., Lissin, N., Wooldridge, L., Choi, E. M. L., Dunbar, P. R., Esnouf, R. M., Sami, M., Boulter, J. M., Rizkallah, P., Renner, C. Sewell, A., van der Merwe, P. A., Jakobsen, B. K., Griffiths, G., Jones, Y. and Cerundolo, V. 2005. Structural and kinetic basis for heightened immunogenicity of T-cell vaccines. J Exp Med 201:1243-1255. IF: 14.5. **Novel insight into enhancing the immunogenicity of peptides for cancer vaccination. I performed T cell activation assays and CD8 dependency evaluation. Cited 80 times. To read the publication, please click the PubMed link button below:...Read More6. High Avidity Antigen-Specific CTL Identified by CD8-Independent Tetramer Staining
Man-Lik Choi, E., Chen, J., Wooldridge, L., Salio, M., Lissina, A., Lissin, N., Hermans, I. F., Silk, J. D., Mirza, F., Palmowski, M. J., Dunbar, P. R., Jakobsen, B. K., Sewell, A. K. and Cerundolo, V. 2003. High Avidity Antigen-Specific CTL Identified by CD8-Independent Tetramer Staining. J Immunol 171:5116-5123. IF: 5.745. To read the publication, please click the PubMed link button below:...Read More5. Anti-CD8 antibodies can inhibit or enhance peptide-MHC class I (pMHCI) multimer binding: this is paralleled by their effects on CTL activation and occurs in the absence of an interaction between pMHCI and CD8 on the cell surface
Wooldridge, L., Hutchinson, S. L., Choi, E. M., Lissina, A., Jones, E., Mirza, F., Dunbar, P. R., Price, D. A., Cerundolo, V., and Sewell, A. K. 2003. Anti-CD8 antibodies can inhibit or enhance peptide-MHC class I (pMHCI) multimer binding: this is paralleled by their effects on CTL activation and occurs in the absence of an interaction between pMHCI and CD8 on the cell surface. J Immunol 171:6650-6660. IF: 5.745. **First paper to describe the pMHCI/CD8 independent effects of anti-CD8 antibodies. Cited 29 times. To read the publication, please click the PubMed link button below:...Read More4. The CD8 T cell coreceptor exhibits disproportionate biological activity at extremely low binding affinities
Wooldridge, L., Hutchinson, S. L., Tafuro, S., Laugel, B., Glick, M., Boulter, J. M., Jakobsen, B. K., Price, D. A., and Sewell, A. K. 2003. The CD8 T cell coreceptor exhibits disproportionate biological activity at extremely low binding affinities. J Biol Chem 278:24285-24293. IF: 5.328. **This paper makes an important contribution to what is known about the requirements for T cell receptor triggering. Cited 58 times. To read the publication, please click the PubMed link button below:...Read More3. Framework for veterinary education and training
Wooldridge, L. 2003. Framework for veterinary education and training. Vet Record 152:375. IF: 1.482. To read the publication, please click the PubMed link button below:...Read More2. CD8 null pMHCI tetramers enable an assessment of CTL quality
Wooldridge, L., Price, D., Man-Lik Choi, E., Mirza, F., Dunbar, P.R., Cerundolo, V. and Sewell, A.K. 2003 . Immunology 110:S120. IF: 3.302. To read the publication, please click the PubMed link button below:...Read More1. HIV strategically targets HIV specific T cells
Wooldridge, L., and Sewell, A. K. 2002. HIV strategically targets HIV specific T cells. Trends in Immunology 23:474. IF: 9.533. To read the publication, please click the PubMed link button below:...Read More
34. Human beta-Cell Killing by Autoreactive Preproinsulin-Specific CD8 T Cells Is Predominantly Granule-Mediated With the Potency Dependent Upon T-Cell Receptor Avidity.
Knight, R. R., D. Kronenberg, M. Zhao, G. C. Huang, M. Eichmann, A. Bulek, L. Wooldridge, D. K. Cole, A. K. Sewell, M. Peakman, and A. Skowera. 2012. Human beta-Cell Killing by Autoreactive Preproinsulin-Specific CD8 T Cells Is Predominantly Granule-Mediated With the Potency Dependent Upon T-Cell Receptor Avidity. Diabetes Aug 30 (Epub).